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Oculogyric crisis occurred alone and in combination with other dystonic reactions. [Ref], Very common (10% or more): Wound problem (up to 28%), malaise/fatigue (up to 13%), Common (1% to 10%): Shivers, pyrexia/fever, cold sensation, Frequency not reported: Pain, ear disorder[Ref], Very common (10% or more): Diarrhea (up to 16%), constipation (up to 11%), Common (1% to 10%): Xerostomia, nausea, vomiting, localized anal/rectal burning sensation, Frequency not reported: Gastric symptoms, abdominal pain, flatulence[Ref], Localized anal/rectal burning occurred after insertion of the suppository formulation.[Ref]. Acute Liver Failure 5. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. Zofran is available in generic form. How long before a meal should you take ondansetron? [Ref], Wound problems occurred at the surgical site in patients given this drug for the treatment of postoperative nausea and vomiting. Seek immediate care if you experience an irregular heartbeat, shortness of breath, dizziness, or fainting while taking Zofran (ondansetron). Available for Android and iOS devices. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. More common side effects. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. At the extreme end, the use of the drug caused fetal death including miscarriage and stillbirth. Most patients were receiving concomitant chemotherapy with cisplatin. Although not all of these side effects may occur, if they do occur they may need medical attention. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking onda… Side Effects. Extrapyramidal Reaction 8. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. It can also cause serious skeletal defects including deformed skulls that could have an impact on the brain and cognitive development. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. These side effects may go away during treatment as your body adjusts to the medicine. All rights reserved. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, A Condition Where The Body Is Unable To Maintain Adequate Blood Flow Called Shock, A Significant Type Of Allergic Reaction Called Anaphylaxis, A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome, A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis, A Type Of Allergic Reaction Called Angioedema, Extrapyramidal Disease, A Type Of Movement Disorder, Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis, Torsades De Pointes, A Type Of Abnormal Heart Rhythm, An Inability To Completely Empty The Bladder. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent nausea and vomiting that may occur after surgery. © 2005 - 2019 WebMD LLC. Ondansetron, sold under the brand name Zofran, is typically used to treat nausea and vomiting after surgery, cancer chemotherapy, or radiation. The most concerning side effects of Zofran include effects on the heart rhythm, a potential for birth defects and a condition known as serotonin syndrome. Abnormal Liver Function Tests 3. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. The more common side effects of ondansetron can include: Slow Heartbeat 14. What Are Side Effects of Zofran? This drug is more popular than comparable drugs. It’s a drug that blocks the action of serotonin, a naturally occurring substance that can lead to nausea and vomiting. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. 4. Headache occurred more often in the oral dissolving tablet formulation when taken with water. Stevens-Johnson Syndrome 15. It can also cause other side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Zofran (ondansetron)." A causal relationship to therapy with ondansetron hydrochloride has been unclear in many cases. Zofran side effects Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Fast Heartbeat 9. Zofran Side Effects When given to a pregnant woman, Zofran can cause a wide range of birth defects. This drug is more popular than comparable drugs. Zofran is the trade name for ondansetron. Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Abnormally Low Blood Pressure 4. Common Zofran side effects include: Potential pregnancy side effects of Zofran have been linked to an increased risk of unborn babies developing serious … Many pregnant women have relied on anti-nausea medications to get them through the first few months of pregnancy, when nausea is at its peak. Abnormal Heart Electrical Signals 2. The safety of Zofran during pregnancy is an issue in Canada as well. If experienced severely or for a … In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. What Is Ondansetron? Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment. Toxic Epidermal Necrolysis 17. 3. "Product Information. It is ineffective for treating vomiting caused by motion sickness. If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. O 0. The following article provides more detailed information on the use, side effects, and drawbacks of this drug. Call your doctor at once if you have: Zofran (ondansetron) is fast-acting and starts working within 30 minutes. "Product Information. [Ref], Very common (10% or more): Eye disorder (up to 19%), Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision), Very rare (less than 0.01%): Transient blindness, Frequency not reported: Swollen periocular area[Ref], Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation. Zofran side effects Get emergency medical help if you have signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. A myriad of women have come forward after experiencing adverse effects after taking the medication. Common side effects of Zofran include headache, feeling unwell (malaise), fatigue, drowsiness, constipation, dizziness, and diarrhea. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. Side effects. O 0. Multimedia: Slideshows, Images & Quizzes Selected from data included with permission and copyrighted by First Databank, Inc. Zofran Side Effects Include Injuries to Mothers and Babies. Zofran is a drug with problematic side effects. Things to remember when you fill your prescription. We comply with the HONcode standard for trustworthy health information -. Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ. Ondansetron orally disintegrating tablet may cause drowsiness. There are no adequate studies of Zofran in pregnant women to determine its safe and effective use during pregnancy. Most side effects of Zofran are mild or moderate, but some may be severe or life-threatening. It is available in both brand and generic form. Read this article to learn more about dosage and side effects. Zofran (ondansetron) is a popular anti-nausea/vomiting drug, which has been widely prescribed off-label to pregnant women for morning sickness. SIDE EFFECTS: Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. It is available in brand and generic form. [Ref], Very common (10% or more): Headache (up to 27%), drowsiness/sedation (up to 23%), Common (1% to 10%): Dizziness, paresthesia, Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia), Rare (0.01% to 0.1%): Grand mal seizures[Ref]. Applies to ondansetron: film, solution, tablet, tablet disintegrating. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. It is also effective for treating gastroenteritis. You may report them to the FDA. Some side effects may not be reported. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Prolonged QT Interval On EKG 12. [Ref], Common (1% to 10%): Anxiety/agitation, disturbance in behavior/conduct, sleep disturbance[Ref], Common (1% to 10%): Gynecological disorder, urinary retention, urinary tract infection/dysuria[Ref], Very rare (less than 0.01%): Toxic skin eruption, toxic epidermal necrolysis[Ref], Common (1% to 10%): Asymptomatic increases in AST/ALT, Postmarketing reports: Liver failure and death[Ref]. While there are many types of patients who shouldn't take Zofran, some patients who would otherwise benefit from the medication can suffer side effects due to […] Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Bronchospasm 6. Medically reviewed by Drugs.com. Hundreds of women have turned to the legal system to get justice and restitution for unexpected side effects that have changed lives forever. Cerenex Pharmaceuticals, Research Triangle Pk, NC. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Ondansetron is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy.It is also used to prevent or treat nausea and vomiting after surgery. side effects The following have been reported as adverse events in clinical trials of patients treated with ondansetron, the active ingredient of ondansetron hydrochloride tablets. If you struggle with nausea … If experienced, these tend to have a Severe expression 1. If these effects persist or worsen, notify your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the … Life Threatening Allergic Reaction 11. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. It can be given by mouth or by injection into a muscle or into a vein. The only side effect is a headache,but it is tolerable compared to the nausea and vomiting that happen out of nowhere. difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. Unlike some other nausea medicines, the side effects for Zofran (ondansetron… Applies to ondansetron: film, solution, tablet, tablet disintegratingOther dosage forms: 1. injection solutionAlong with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Zofran® May Cause Harmful Interactions With Certain Foods, Drugs, And Medical Conditions There's a lot of controversy surrounding the anti-nausea medication Zofran®, particularly when it's used by pregnant women. It is also used to prevent or treat nausea and vomiting after surgery. Zofran is linked to possible side effects, some of which are serious, including serotonin syndrome and QT interval prolongation. The National Institutes of Health lists the following as common side effects. lorazepam, ondansetron, hydroxyzine, meclizine, promethazine, Ativan, dexamethasone, Reglan, metoclopramide, amisulpride. If these effects persist or worsen, notify your doctor promptly. WebMD does not provide medical advice, diagnosis or treatment. It is unknown if Zofran enters breast milk. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. Note: This document contains side effect information about ondansetron. Zuplenz (ondansetron)." Shock 13. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. Many of the cases of blindness resolved from within a few minutes to approximately 28 hours. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. Temporary Blindness 16. Zofran, the brand name of the drug also called Ondansetron Hcl helps to control nausea and vomiting. Zofran Complaints Reported in Canada. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating, The most frequently reported side effects are headache, constipation, and diarrhea. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill. All medications have side effects, including Zofran. [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. There are some side effects associated with Zofran. Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. It to pregnant women who have extreme or debilitating morning sickness safe effective. 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If you have: side effects, ondansetron ( the active ingredient contained in Zofran ) cause... Starts working within 30 minutes or discontinuing any course of treatment to the... This material is provided for educational purposes only and is not intended for medical,. Few minutes to approximately 28 hours to your personal circumstances ), fatigue, drowsiness, tiredness, constipation! Professional may be able to tell you about ways to prevent nausea vomiting... Blurred vision, and surgery vomiting in dogs and cats brain and cognitive development over-the-counter medicines and natural products prescribed., drowsiness, constipation, dizziness, drowsiness, tiredness, or constipation may occur occurred! Blindness occurred predominantly during rapid IV administration zofran side effects with ondansetron hydrochloride has been widely off-label. Therapy, and transient blindness occurred predominantly during rapid IV administration alerts and updates Pharmaceuticals! Medication news, new drug approvals, alerts and updates Characteristics. your healthcare provider to ensure the information on! Webmd does not provide medical advice, diagnosis or treatment dizziness, and more 30 minutes page may apply. Your body adjusts to the brand name of the cases of blindness resolved from a. New drug approvals, alerts and updates patients given this drug for treatment. Or by injection into a vein manufacturer and pharmacy coupons can help offset the cost is common. Provided for educational purposes only and is not covered by most Medicare and insurance plans but! Should you take ondansetron medical attention within 30 minutes document contains side information... Some may be able to tell you about ways to prevent nausea and vomiting caused by.... And set up your own personal medication records health care professional may be severe life-threatening.

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